Inflammation & Immunological Models

The ability to control the immune system and inflammation has always been regarded as one of the most delicate targets of the drug development industry. On the one hand, working to empower the immune response can sometimes lead to the development of an autoimmune reaction, on the other hand, aiming at regulating an inflammatory reaction pose the risk of creating a too contained immune system which may stop providing protection.

Screening lids for their anti-inflammatory or pro-inflammatory potential is something we are great at. With our battery of in-vitro assays, that use mouse and human inflammatory cells as well as state-of-the-art multichannel flow-cytometry, multiplex elisa and quantitative PCR, we can ensure that if you have a lid, we will find it.

For the next step, once the lid/s or your choice are identified, we will test them in the most suited in-vivo animal model. If you are aiming at treating skin, gut, joints, or any other.

Our services support an array of therapeutic disciplines

Cannabis based therapy

Microbiome

Pharmaceuticals

Medical devices

Biological therapy

Nutraceuticals

Cell & Gene based Therapy

Inflammation & Immunological Models

  • Models available: Crohn’s/Colitis (DSS, TNBS).
  • Species available: Mouse, Rat.
  • Standard assessments: Body weight, clinical signs, scoring, histology.
  • Additional assessments: Cytokine levels (ELISA), PCR.
  • Models available: Collagen.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, Von Frey test, incapacitance (weight bearing test), grip strength.
  • Additional assessments: Rota-rod, histology, Immunostaining, blood chemistry & biochemistry, cytokine levels (ELISA), PCR.
  • Models available: CFA.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, Von Frey test, incapacitance (weight bearing test), grip strength.
  • Additional assessments: Rota-rod, histology, immunostaining, blood chemistry & biochemistry, cytokine levels (ELISA), PCR.
  • Models available: Surgical.
  • Species available: Rat.
  • Standard assessments: Body weight, clinical signs, Von Frey test, incapacitance (weight bearing test), grip strength.
  • Additional assessments: Rota-rod, histology, Immunostaining, blood chemistry & biochemistry, cytokine levels (ELISA), PCR.
  • Models available: Surgical.
  • Species available: Rat.
  • Standard assessments: Body weight, clinical signs, Von Frey test, incapacitance (weight bearing test), grip strength.
  • Additional assessments: Rota-rod, histology, immunostaining.
  • Models available: Surgical.
  • Species available: Rat.
  • Standard assessments: Body weight, clinical signs, Von Frey test, incapacitance (weight bearing test), grip strength.
  • Additional assessments: Rota-rod, histology, immunostaining.
  • Models available: Surgical.
  • Species available: Rat.
  • Standard assessments: Body weight, clinical signs, histology, immunostaining.
  • Additional assessments: X-Ray.
  • Models available: MuSK or AchR induced EAMG.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, grip strength, antibody levels (ELISA), histology, bungarotoxin staining.
  • Additional assessments: EMG.
  • Models available: MOG & PT induced EAE.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, neurological score, histology.
  • Models available: Imiquimod.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, scoring, histology.
  • Additional assessments: Immunostaining, PCR.
  • Models available: Oxazolone.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, scoring, histology.
  • Additional assessments: Immunostaining, PCR.
  • Models available: Substance P, Capsaicin, Acetone-Ether-Water (AEW).
  • Species available: Mouse, Rat.
  • Standard assessments: Body weight, clinical signs, scratching score.
  • Additional assessments: Histology.
  • Species available: Mouse, Rat, Rabbit, Pig.
  • Standard assessments: Body weight, clinical signs, erythema & edema.
  • Models available: Punch.
  • Species available: Mouse, Rat, Pig.
  • Standard assessments: Body weight, clinical signs, wound closure measurement, histology.
  • Additional assessments: Immunostaining.
  • Models available: Bile duct ligation (BDL) model.
  • Species available: Mouse.
  •  Standard assessments: itching, clinical signs, jaundice, food consumption, histopathology (masson trichrome and H&E).
  • Models available: Liver Fibrosis – CCL4 model, Lung Fibrosis & ARDS.
  • Species available: Mouse. 
  • Standard assessments: Clinical signs, Broncho-alveolar lavages (Lung), counts of infiltrating cells, ELISA or Multiplex for quantitation of cytokines, histopathology (masson-trichrome and H&E), lung weight, food consumption.
  • Models available: Sheep RBC.
  • Species available: Mouse.
  • Standard assessments: Body weight, clinical signs, erythema diameter.
  • Models available: CFA, Carrageenan, Formalin, Capsaicin, LPS.
  • Species available: Rat, mouse.
  • Standard assessments: Body weight, clinical signs, Von Frey test, hot plate, erythema & edema, paw measurement, cytokine levels (ELISA), cell proliferation, survival.
  • Additional assessments: Cytokine levels (ELISA).
  • Models available: Surgical and navigation device.
  • Species available: Sheep.
  • Standard assessments: Body weight, clinical signs, incapacitance (weight bearing test), grip strength.
  • Additional assessments: CT, histology.

Research outcomes - examples

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