Vascular Dementia Model

Neurology



Vascular Dementia Model

Vascular dementia is caused by a sudden low blood supply to the brain, often the consequence of a stroke. The symptoms can  stay silent and will only be noticed after a series of stroke events. The symptoms include cognitive and behavioral changes such as memory loss, deficit of attention, depression.

We have developed an all round vascular dementia preclinical programme including  a pertinent rat model and behavioral tests which recapitulate the symptoms seen in human vascular dementia.

 

Rat model of chronic cerebral hypo-perfusion

 

  • Chronic cerebral hypo-perfusion induced by permanent, bilateral occlusion of both common carotid arteries (BCCAO) in rats, results in a significant white matters lesions, hippocampal neuronal damage, as well learning and memory impairment.

 

  • The technique decreases blood flow in the cerebral cortex and hippocampus by 40-80% for several month, leading to cognitive deficiencies.

 

Here is a list of behavioral tests we used in our vascular dementia preclinical protocols:

  • Morris water maze
  • Object recognition test
  • Social recognition test
  • Open field
  • Passive avoidance test
  • Rota-Rod

 

Passive Avoidance test is routinely used to assess learning and memory in rodents. Here, we test our vascular dementia-induced rat model against sham rat model as control.

The results presented below measure the latency to reach the hidden platform on Day 84 and 112 during three trials of learning.
4.4 Vascular dementia-Morris water maze1 4.4 Vascular dementia-Morris water maze2

 

 

 

 

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