 |
OUR SERVICES> INFLAMMATION & INFLAMMATORY PATHWAYS |
Inflammation and Inflammatory Pathways
Pharmaseed Bioservices offers a unique battery of pre-clinical services that enable customers to screen potential anti-inflammatory agents as well as identify novel therapeutic targets. Screening of compounds can be performed in existing well-characterized animal models as well as in newly developed animal models tailored to a specific tested item. Our expanded battery of models includes studies of inflammation and inflammatory pathways, including in vivo models of inflammation and autoimmune diseases, as well as complementary in vitro and ex vivo work.
Therapeutic Areas:
Acute/chronic screening models
Carrageenin-induced paw edema in rats
Formalin-induced acute inflammation in mice
Cotton pellet-induced granuloma in mice/rats
Arthritis
Rheumatoid arthritis models
Collagen-induced arthritis model in mice/rats
Osteoarthritis models
CFA-induced osteoarthritis model in rats
Induction of osteoarthritis model by transaction of the medial collateral ligaments and medial meniscus in rats
Inflammatory Bowel Disease (IBD)
DSS-induced colitis in mice (Balb/c, C57Bl/6)
TNBS-induced colitis in mice
Contact Dermatitis
Multiple Sclerosis (EAE)
Spinal cord homogenate-induced EAE in mice
MOG35-55-induced EAE in mice
PLP induced EAE in mice
In vitro model of inflammation:
IL-6, NO production and iNOS induction in RAW264.7 cell line by LPS and IFN
|
|
|
|
