Diabetes Mouse/Rat Models

Our Added Value

Our main purpose is to provide the most relevant data that will determine the translational efficacy of the tested technology.

This is done with an array and combination of a number of risk factors such as

• Age
• Genetic susceptibility utilizing transgenics mice and rats
• High-fat (“western”) diet
• Male/Female ratio
• Background diseases

 

Induction

Induction is usually performed via a direct injection of Streptozotocin (stz) that causes a destruction of pancreatic beta cells.

Depending on the dosing of stz, either type I or type II diabetes is observed.

Other methods are also available such as:

• Transgenic diabetic-prone mice and rats
• Surgically-induced diabetes via pancreatectomy

 

Diabetes-related Complications Evaluation

 

• Ischemia Evaluations
• Obesity
• Chronic Peripheral Complications
• Kidney Function Evaluation

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