Aged Mice

CNS



Aged Mice- Not Young But Relevant

Aged mice: available models

 

Aged mice related models are based on animals that begin to exhibit cognitive, biochemical and brain metabolism deficits starting at approximately 12 months of age.

 

These models can be used to assess efficacy in age-related cognitive decline associated with Parkinson’s, Alzheimer’s diseases and other diseases linked with aging. These studies can also be combined with other models such as scopolamine-induced amnesia.

 

Aging Research:Introducing Not Young But Relevant

 

The need for better animal models in aging preclinical research is based on the necessity to reduce first clinical phases high attrition rate. Indeed, how does one explain the discrepancy between positive preclinical results and failure in early clinical phases? The translation value is too low.

Our answer: animal models need to better mimic the development of the human disease.

 

 

Not Young But Relevant: better models for Parkinson’s disease

Our new available models for Parkinson’s disease integrate the major known risk factors in the development of the disease:

  • age (>12 month old)
  • inflammation (LPS)
  • toxins (MPTP)
  • genetics (α-synuclein. PAC-Tg(SNCAWT); Snca-/- mice)
  • western diet (oxidative stress)
  • gender

 

Behavioral (Pole test, Rota-Rod test, Force Swim test, Social Recognition test, Open field activity test…)  as well as histology studies show that these models correctly recapitulate the physiopathology of the human disease. In particular, we observed in old animals, after LPS triggered inflammation and MPTP chronic treatment, the formation of α-synuclein aggregates and a reduction in Tyrosine Hydroxylase positive neurons.

We anticipate that these animal models will prove useful to better predict human response to tested items.

 

Histology analysis on Old animals after MPTP treatment
not-young-but-relevant-aging-alpha-synuclein

Rota-Rod test on Old vs Young animals after chronic MPTP treatment
not-young-but-relevant-aging-rota-rod-MPTP

 

 

 

Pole Test on Old versus Young animals after LPS induction
not-young-but-relevant-aging-LPS

Not Young But Relevant: join the discussion

 

At Pharmaseed, Not Young But Relevant is more than a new animal model, it is an ongoing discussion on the latest scientific results, news and views to improve neurodegenerative diseases clinical attrition rate: from new available models to basic research reproducibility issues.

If you want to follow our news and enter the discussion, you are welcome to join our Pharmaseed Translational Group on Linked In.

 

 

Dr Y and Dr NoClue from Pharmaseed Ltd

 

Not Young But Relevant in the world

 

  • Our models are available through our offices in Europe and the USA

For more information, please visit:

Pharmaseed USA and/or Pharmaseed Europe

 

  • At Pharmaseed, science comes first! we regularly present the science behind our new models at various conferences and meetings, stay tuned for where to find us next!

 

FENS 2016

Biomed 2016

BioEurope Spring 2016

Biomed 2015

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