Vascular dementia is caused by a sudden low blood supply to the brain, often the consequence of a stroke. The symptoms can stay silent and will only be noticed after a series of stroke events. The symptoms include cognitive and behavioral changes such as memory loss, deficit of attention, depression.
We have developed an all round vascular dementia preclinical programme including a pertinent rat model and behavioral tests which recapitulate the symptoms seen in human vascular dementia.
Rat model of chronic cerebral hypo-perfusion
Here is a list of behavioral tests we used in our vascular dementia preclinical protocols:
Passive Avoidance test is routinely used to assess learning and memory in rodents. Here, we test our vascular dementia-induced rat model against sham rat model as control.
The results presented below measure the latency to reach the hidden platform on Day 84 and 112 during three trials of learning.